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  • Title: [Significance of the reciprocal relationship of monoaminergic systems of the brain in the pharmacological compensation of 6-hydroxydopamine-induced behavior disorders in animals].
    Author: Gromova EA, Semenova TP.
    Journal: Biull Eksp Biol Med; 1989 Jan; 107(1):52-4. PubMed ID: 2521566.
    Abstract:
    The paper studied the methods of compensation of the abnormal emotional behaviour by means of pharmacological substances, which change the content of biogenic amines. The experiments made in the Wistar rats (n-54) whose frustration reaction was diminished by neonatal treatment of 6-OHDA. It was established that recovery of the disturbances in the frustration reaction in the animals with chronic brain system activity deprivation can be achieved not only by the activation of NA system (L-DOPA, DOPS) but also by deactivation of the 5-HT brain system activity (PCPA). These findings confirm suggestion about existence of reciprocal relationship between NA and 5-HT brain systems.
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