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  • Title: Huperserines A-E, Lycopodium alkaloids from Huperzia serrata.
    Author: Jiang WW, Liu F, Gao X, He J, Cheng X, Peng LY, Wu XD, Zhao QS.
    Journal: Fitoterapia; 2014 Dec; 99():72-7. PubMed ID: 25218968.
    Abstract:
    A phytochemical study on Huperzia serrata led to the isolation of four new 5-deoxyfawcettimine-related Lycopodium alkaloids, huperserines A-D (1-4), and one new lycodine-type alkaloid, huperserine E (5). Their structures were elucidated based on spectroscopic data, including 1D and 2D NMR techniques. 5-Carbonyl or 5-hydroxyl group is a typical characteristic of lycopodine- and fawcettimine-type alkaloids. This is the first report of the 5-deoxyfawcettimine type Lycopodium alkaloids. In vitro acetylcholinesterase (AChE) inhibitory activity assay showed that huperserine E exhibited moderate anti-AChE activity with an IC₅₀ value of 6.71 μM.
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