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  • Title: Use of a high b-value for diffusion weighted imaging of peritumoral regions to differentiate high-grade gliomas and solitary metastases.
    Author: Han C, Huang S, Guo J, Zhuang X, Han H.
    Journal: J Magn Reson Imaging; 2015 Jul; 42(1):80-6. PubMed ID: 25223489.
    Abstract:
    BACKGROUND: To determine whether apparent diffusion coefficient (ADC) values obtained using a b-value of 3000 s/mm(2) can be used to differentiate high-grade glioma (HGG) from solitary metastases (SM). METHODS: Forty patients underwent conventional magnetic resonance imaging (MRI) and standard and high b-value diffusion-weighted imaging (DWI). Minimum, maximum, and mean ADC values (ADCMIN , ADCMAX , and ADCMEAN , respectively) were measured from ADC maps obtained for the two b-values for each subject. ADC ratios were also measured. A receiver operating characteristic (ROC) curve analysis was used to determine the cutoff ADC value for distinguishing between HGG and SM. RESULTS: All ADC values for the peritumoral region of the HGGs examined were lower than those for the SM. Furthermore, a larger statistical difference was observed for ADCMIN , ADCMAX , and ADCMEAN values at a b-value of 3000 s/mm(2) versus 1000 s/mm(2) (P < 0.0001, P = 0.0010, and P = 0.0001 versus P = 0.0001, 0.0030, and 0.0002, respectively). A discriminant analysis identified the greatest log likelihood for the ADCMIN values obtained at a b-value of 3000 s/mm(2) , and the cutoff value for differentiating HGG and SM was 0.890 × 10(-3) mm/s(2) . CONCLUSION: ADC values from DWI using a high b-value were found to distinguish HGG and SM. The lowest degree of overlap was obtained when an ADCMIN value was obtained at a b-value of 3000 s/mm(2) .
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