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  • Title: The early and late sea urchin histone H4 mRNAs respond differently to inhibitors of DNA synthesis.
    Author: Jarvis JW, Marzluff WF.
    Journal: Dev Biol; 1989 Apr; 132(2):325-30. PubMed ID: 2522406.
    Abstract:
    The effect of inhibiting DNA synthesis on the concentration of the alpha-histone mRNA and the late histone mRNAs in sea urchin embryos was measured. The alpha-histone mRNA concentrations did not change, while the late histone mRNA concentrations were rapidly reduced at the three developmental stages (morula, blastula, and mesenchyme blastula) tested. The rapid degradation of the late histone mRNAs was prevented when protein synthesis was inhibited.
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