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  • Title: A new antimicrobial anthrone from the leaf latex of Aloe trichosantha.
    Author: Oumer A, Bisrat D, Mazumder A, Asres K.
    Journal: Nat Prod Commun; 2014 Jul; 9(7):949-52. PubMed ID: 25230501.
    Abstract:
    Phytochemical investigation of the leaf latex of Aloe trichosantha by preparative TLC gave two closely related anthrones, aloin A/B (1) and aloin-6'-O-acetate A/B (2). The identity of the compounds was established from HRESI-MS, 1H, 13C, DEPT, HMQC and HMBC spectral and chemical data. Whilst aloin A/B occurs in several Aloe species, aloin-6'-O-acetate A/B was isolated for the first time. The isolated compounds inhibited growth of several bacterial and fungal pathogens with minimum inhibitory concentration (MIC) from 10 to 400 microg/mL and 800 to 1000 microg/mL, respectively.
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