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  • Title: Neurofibromatosis type 1 associated with vertebrobasilar dolichoectasia and pontine ischemic stroke.
    Author: Giannantoni NM, Broccolini A, Frisullo G, Pilato F, Profice P, Morosetti R, Di Lella G, Zampino G, Della Marca G.
    Journal: J Neuroimaging; 2015; 25(3):505-6. PubMed ID: 25230986.
    Abstract:
    Neurofibromatosis type 1 (NF1) is a heterogeneous, common, neurocutaneous disorder presenting different complications during a life span, including cerebrovascular dysplasia. To our knowledge this is the first reported case of NF1 associated with vertebrobasilar dolichoectasia and pontine ischemic stroke. We describe a 57-year-old man with NF1 who presented an acute onset right-sided facial palsy and hemiplegia, dysarthria, and gait imbalance. Magnetic resonance imaging showed an acute left paramedian pontine infarct and a hypoplastic right vertebral artery. Brain Computed Tomography Angiography revealed the occurrence of vertebrobasilar dolichoectasia. Co-occurrence of VBD and NF1 might not be merely casual and it may significantly heighten the mortality rate in this multisystem disorder. We suggest a possible role of VBD in the genesis of our patient's clinical-radiological features and prompt the early detection of asymptomatic arteriopathy in individuals with NF1 in order to ameliorate patients' quality of life and life expectancy.
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