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  • Title: Cataract prevention in diabetic Octodon degus with Pfizer's sorbinil.
    Author: Datiles MB, Fukui H.
    Journal: Curr Eye Res; 1989 Mar; 8(3):233-7. PubMed ID: 2523284.
    Abstract:
    The Octodon degus has been reported to have higher aldose reductase activity in the lens compared to the gerbil and rat. When made diabetic the degus develop cataracts within 4 weeks. We have been able to completely prevent cataract formation in diabetic degus using Pfizer's sorbinil for up to 6 months. This is further evidence of the role of aldose reductase in the formation of cataracts in diabetes.
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