These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Interleukin 4 dependent induction of IgE synthesis and CD23 expression by the supernatants of a human helper T cell clone.
    Author: Vercelli D, Leung DY, Jabara HH, Geha RS.
    Journal: Int Arch Allergy Appl Immunol; 1989; 88(1-2):119-21. PubMed ID: 2523353.
    Abstract:
    The supernatants of the human alloreactive helper T cell clone A1, which secretes interleukins (IL) 4 and 5, could induce IgE synthesis by normal peripheral blood mononuclear cell and expression of Fc epsilon R2/CD23 on normal human monocytes. Both effects were IL-4 dependent, since they could be induced by recombinant IL-4 alone and were inhibited by an anti-IL-4 antibody. The activation of such clones may contribute to the high IgE production and the high percentage of circulating CD23+ monocytes observed in allergic disorders.
    [Abstract] [Full Text] [Related] [New Search]