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  • Title: The T-cell receptor delta chain locus is disrupted in the T-ALL associated t(11;14)(p13;q11) translocation.
    Author: Champagne E, Takihara Y, Sagman U, de Sousa J, Burrow S, Lewis WH, Mak TW, Minden MD.
    Journal: Blood; 1989 May 01; 73(6):1672-6. PubMed ID: 2523742.
    Abstract:
    Two T-ALL patients carrying a t(11;14)(p13;q11) translocation were analyzed. Southern blotting experiments demonstrated that both patients had rearranged their J delta genes and that the translocation involved the delta locus in both cases. In one patient, cloning, restriction mapping, and sequencing showed that the translocation occurred on a D delta 1-D delta 2-J delta 2 rearranged gene. In addition, the rearrangement on chromosome 11 occurred in both patients within a segment of less than or equal to 2 kb showing the presence in this region of a point of recurrent recombination.
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