These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Expression of low-affinity receptor for IgE (Fc epsilon RII, CD23) and IgE-BF (soluble CD23) release by lymphoblastoid B-cell line RPMI-8866 and human peripheral lymphocytes of normal and atopic donors.
    Author: Bujanowski-Weber J, Brings B, Knöller I, Pfeil T, König W.
    Journal: Immunology; 1989 Apr; 66(4):505-11. PubMed ID: 2523859.
    Abstract:
    The low-affinity receptor for IgE (CD23) as well as the soluble IgE-binding factors (IgE-BF, sCD23) are important factors in IgE antibody regulation. The CD23 expression and the concomitant release of CD23 were analysed from the lymphoblastoid B-cell line RPMI-8866 and from peripheral blood lymphocytes (PBL) of healthy volunteers as well as atopic patients. CD23 expression and sCD23 release of RPMI-8866 cells were dependent on the stage of culture. While CD23 expression decreased with increasing time of culture (Day 1-3), the sCD23 release was enhanced during the culture period. Cytokines such as IL-4, IL-2, TNF alpha and IFN-gamma exerted various effects on the target cells depending on the culture period. CD23 expression on normal lymphocytes was lower compared with the expression on atopic cells. Lymphokines (IL-2, IL-4) as well as mitogens (PHA, Con A) enhanced CD23 expression and IgE-BF (sCD23) release. The degree of enhancement was always higher with atopic cells compared with the results obtained with cells of normal donors.
    [Abstract] [Full Text] [Related] [New Search]