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  • Title: Diurnal rhythm of beta-endorphin in neonates.
    Author: Sankaran K, Hindmarsh W, Tan L.
    Journal: Dev Pharmacol Ther; 1989; 12(1):1-6. PubMed ID: 2524371.
    Abstract:
    In an attempt to prove whether beta-endorphin diurnal rhythm existed in neonates, 17 infants with a mean (+/- SD) gestational age of 31.7 +/- 4.8 weeks and a birth weight of 1,790 +/- 898 g were studied at a mean postnatal age of 3.3 +/- 0.5 days. Plasma samples were obtained from a pre-existing umbilical arterial line at 09.00 h, noon and 15.00 h. Mean plasma concentrations of beta-endorphin were 68.3 +/- 27.7, 54.5 +/- 13.7, and 45.1 +/- 10.8 pg/ml, respectively. Highly significant (p = 0.0002) variation of plasma beta-endorphin concentration was observed in these neonates suggesting the presence of a diurnal rhythm of beta-endorphin in neonates. It is important to specify the time of collection of blood samples for determination of opiates in neonates.
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