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  • Title: Acyclovir-resistant, foscarnet-sensitive oral herpes simplex type 2 lesion in a patient with AIDS.
    Author: MacPhail LA, Greenspan D, Schiødt M, Drennan DP, Mills J.
    Journal: Oral Surg Oral Med Oral Pathol; 1989 Apr; 67(4):427-32. PubMed ID: 2524706.
    Abstract:
    We report the case of an immunocompromised patient with AIDS in whom developed a perioral and several intraoral HSV 2 lesions that persisted for more than 1 year. The virus was resistant to acyclovir but was sensitive to foscarnet. Viral isolates were thymidine kinase negative. The lesions resolved with intravenous foscarnet therapy given over a 15-week period, and when last seen, 8 months after foscarnet was discontinued, the patient had not had a recurrence.
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