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  • Title: Association of DLX3 gene polymorphism and dental caries susceptibility in Japanese children.
    Author: Ohta M, Nishimura H, Asada Y.
    Journal: Arch Oral Biol; 2015 Jan; 60(1):55-61. PubMed ID: 25247779.
    Abstract:
    OBJECTIVE: In this study, we investigated whether single nucleotide polymorphisms (SNPs) in DLX3 are associated with dental caries susceptibility in Japanese children. DESIGN: Genomic DNA of 201 Japanese children was extracted from buccal epithelial cells. The subjects were divided into two groups: 'low level' group with <10,000 colony forming units (CFU) of Streptococcus mutans/mL saliva (level 0) and 'high level' group with ≥ 10,000 CFU/mL (more than level 1). Each group was further divided according to decayed, missing, filled teeth (dmft) into low caries experience (dmft ≤2) and high caries experience (dmft ≥ 3). Seven SNPs in DLX3 were genotyped using TaqMan1® SNP Genotyping Assay. RESULTS: Statistical significant association was observed between DLX3 (rs2278163) and caries experience in 'high level Mutans streptococci' group. CONCLUSION: These findings suggest that rs2278163 SNP of DLX3 might be associated with dental caries susceptibility in Japanese children. T and C alleles of rs2278163 SNP may potentially be involved in caries susceptibility and caries protection respectively.
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