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  • Title: Highly stereoselective synthesis of functionalized pyrrolo[3,2-c]quinolines via N-heterocyclic carbene catalyzed cascade sequence.
    Author: Yang YJ, Zhang HR, Zhu SY, Zhu P, Hui XP.
    Journal: Org Lett; 2014 Oct 03; 16(19):5048-51. PubMed ID: 25247840.
    Abstract:
    An N-heterocyclic carbene-catalyzed stereoselective Michael-Mannich-lactamization cascade reaction of tosyl-protected o-amino aromatic aldimines and 2-bromoenals for the construction of functionalized pyrrolo[3,2-c]quinolines with three consecutive stereocenters was achieved in good yields with excellent diastereo- and enantioselectivities.
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