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  • Title: The majority of mouse spontaneous rosette-forming cells of thymic origin belong to the Ly-2+ subset.
    Author: Lepault F, Fache MP, Gagnerault MC, Bach JF, Dardenne M.
    Journal: Eur J Immunol; 1989 Apr; 19(4):605-9. PubMed ID: 2525098.
    Abstract:
    Spontaneous sheep erythrocyte rosette-forming T cells (T-sRFC) found in normal mouse spleen are specific for the xenogeneic species of red cells and are distinct from human E rosettes as illustrated by their persistence after sheep red blood cell (SRBC) incubation with anti-LFA-3 monoclonal antibodies directed against SRBC molecule binding to the E rosette receptor. We confirm here using monoclonal antibodies that T-sRFC are Thy-1+CD3+. Additionally, using cell separation techniques based on panning and cell sorting, it is shown that the vast majority of spleen sRFC have the L3T4-Ly-2+ phenotype. As already shown for anti-Thy-1 antibodies, anti-CD3 and anti-Ly-2 antibodies block rosette formation, whereas antibodies to more abundant cell surface antigens (T200, H-2Db) are not inhibitory. These data suggest that the interaction of T-sRFC with SRBC occurs at or near the T cell receptor.
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