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  • Title: [Chronic granulocytopenia as a main symptom of T gamma-lymphocytosis].
    Author: Krieger G, Kneba M, Ohms G, Gabius S, Nagel GA.
    Journal: Dtsch Med Wochenschr; 1989 Jul 07; 114(27):1064-8. PubMed ID: 2525466.
    Abstract:
    Routine examination of a 60-year-old woman with long-lasting rheumatic complaints revealed a granulocytopenia in the differential blood count (1% stab cells, 3% segmented) with a normal total leucocyte count (4,200/microliters). It was caused by a lymphoproliferative disease of the granular lymphocytes, which may also be termed T gamma lymphocytosis because of the predominant phenotype. As the lymphocytosis in blood and bone marrow was of minor degree, the diagnosis was confirmed only by immunocytochemical and molecular-genetic demonstration of clonal expansion of the T gamma lymphocytes. The granulocytopenia gradually became more marked and recurrent infections were noted. Treatment with cyclosporin and cortisone brought about remission of the granulocytopenia.
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