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  • Title: Oxime-mediated facile access to 5-methylisoxazoles and applications in the synthesis of valdecoxib and oxacillin.
    Author: Dong KY, Qin HT, Bao XX, Liu F, Zhu C.
    Journal: Org Lett; 2014 Oct 17; 16(20):5266-8. PubMed ID: 25255195.
    Abstract:
    A palladium-catalyzed efficient synthesis of 5-methylisoxazoles via oxime-mediated functionalization of unactivated olefins is described. The reaction affords a variety of 5-methylisoxazoles in moderate to good yields. To further demonstrate the utility of the method, the rapid synthesis of valdecoxib and oxacillin is reported.
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