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Title: Correlation of the interleukin-29 levels in crevicular fluid and plasma with the genetic polymorphism in chronic and aggressive periodontitis patients.
Author: Shivaprasad BM, Pradeep AR.
Journal: Arch Oral Biol; 2015 Jan; 60(1):37-44. PubMed ID: 25255471.
Abstract:
OBJECTIVE: To assess the effect of single nucleotide polymorphism (SNP) on the Interleukin (IL-29) quantity in gingival crevicular fluid (GCF) and plasma of chronic and aggressive periodontitis patients. DESIGN: Patients with periodontal health (n=30), chronic generalized periodontitis (n=30) and generalized aggressive periodontitis (n=30) were subjected to IL-29 quantity estimation in GCF and plasma using enzyme linked immunosorbent assay and was correlated with IL-29 SNP (rs30461) using polymerase chain reaction. RESULTS: IL-29 concentration in GCF and plasma was highest in aggressive periodontitis patients (114.17 ± 95.07pg/ml and 149.69 ± 109.90pg/ml respectively). The least concentration was found in subjects with healthy periodontium (47.50 ± 37.75pg/ml and 54.52 ± 37.53pg/ml) and in chronic periodontitis it was found to be 65.01 ± 41.26pg/ml and 81.17 ± 46.23pg/ml. The difference in the quantity of IL-29 in GCF and plasma among different groups was statistically significant (p<0.001 and p<0.001 respectively). rs30461 polymorphism of IL-29 analysis revealed that difference in the prevalence of A/A, A/G and G/G genotype among three groups was not statistically significant (p=0.097). CONCLUSION: Increased quantity of IL-29 in GCF and plasma of subjects with periodontitis suggests a role in pathogenesis of periodontitis and the SNP (rs30461) is not related to susceptibility to periodontitis in this population of Indian individuals.

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