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  • Title: Ultra-sensitive immunoassay biosensors using hybrid plasmonic-biosilica nanostructured materials.
    Author: Yang J, Zhen L, Ren F, Campbell J, Rorrer GL, Wang AX.
    Journal: J Biophotonics; 2015 Aug; 8(8):659-67. PubMed ID: 25256544.
    Abstract:
    We experimentally demonstrate an ultra-sensitive immunoassay biosensor using diatom biosilica with self-assembled plasmonic nanoparticles. As the nature-created photonic crystal structures, diatoms have been adopted to enhance surface plasmon resonances of metal nanoparticles on the surfaces of diatom frustules and to increase the sensitivity of surface-enhanced Raman scattering (SERS). In this study, a sandwich SERS immunoassay is developed based on the hybrid plasmonic-biosilica nanostructured materials that are functionalized with goat anti-mouse IgG. Our experimental results show that diatom frustules improve the detection limit of mouse IgG to 10 pg/mL, which is ˜100× better than conventional colloidal SERS sensors on flat glass. Ultra-sensitive immunoassay biosensor using diatom biosilica with self-assembled plasmonic nanoparticles.
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