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  • Title: [Demonstration of the lymphokine mechanism of the reinforcement of lymphoid proliferation during liver regeneration in mice].
    Author: Rakhmilevich AL.
    Journal: Ontogenez; 1989; 20(2):192-8. PubMed ID: 2525697.
    Abstract:
    Changes in the ability of mouse splenocytes to proliferate early after partial hepatectomy have been studied. Proliferative activity of mouse splenocytes in mixed lymphocyte culture and in spontaneous proliferation in vitro test increased within 4, 17 and 24 hours after operation as compared with pseudo-operated control. After 4 hours of cultivation splenocytes of partially hepatectomized mice excreted into culture medium factor(s) that enhanced proliferative activity of intact mouse lymphocytes both in vitro and in vivo. The factor is thermolabile, operates nonspecifically, and is produced by T-lymphocytes.
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