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  • Title: Dexamethasone blocks adaptive increase of Na+-Pi cotransport in renal brush border membrane elicited by thyroid hormone.
    Author: Yusufi AN, Moltaji H, Dousa TP.
    Journal: Biochem Biophys Res Commun; 1989 Jun 30; 161(3):1160-5. PubMed ID: 2525901.
    Abstract:
    Dexamethasone administered to rats blocks and/or reverses adaptive increases in the rate of Na+-Pi cotransport, and also in the Na+-dependent binding of [14C]-phosphonoformic acid (PFA) by renal brush border membrane (BBM) vesicles elicited by thyroid hormone (T3). In contrast, dexamethasone had no effect on Na+-independent binding of [14C]-phosphonoformic acid, on Na+-dependent transport of D-glucose or on Na+-dependent binding of phlorizin by BBMV which indicates that its inhibitory effect is specific for Na+-Pi cotransport system of BBM. These findings suggest that glucocorticoids antagonize T3-elicited adaptive enhancement of Na+-Pi cotransport in renal proximal tubules by blocking the T3-stimulated de novo synthesis of Na+-Pi symporters and/or their insertion into BBM.
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