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  • Title: Glial fibrillary acidic protein (GFAP) from goldfish: its localisation in visual pathway.
    Author: Nona SN, Shehab SA, Stafford CA, Cronly-Dillon JR.
    Journal: Glia; 1989; 2(3):189-200. PubMed ID: 2526081.
    Abstract:
    An intermediate filament fraction, isolated from goldfish brain, contains a prominent protein having a molecular weight of 51 kDa. In normal goldfish visual pathway, this protein is present in tectum and tract, but not in optic nerve. A polyclonal antibody raised to this protein clearly labels ependymal glial profiles in tectum and parallel processes in the tract, whereas optic nerve is unlabelled; Müller fibres in the retina are also labelled. A similar, but less prominent, pattern of staining is observed with antibodies, raised elsewhere, against glial fibrillary acidic protein from human and porcine. These results suggest that the 51 kDa protein is a GFAP, demonstrate the heterogeneity of astrocytes in goldfish visual pathway, and are consistent with the idea that GFAP is well conserved in vertebrate phylogeny.
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