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  • Title: UV irradiation inhibits initiation of DNA replication from oriC in Escherichia coli.
    Author: Verma M, Moffat KG, Egan JB.
    Journal: Mol Gen Genet; 1989 Apr; 216(2-3):446-54. PubMed ID: 2526290.
    Abstract:
    Irradiation of Escherichia coli with UV light causes a transient inhibition of DNA replication. This effect is generally thought to be accounted for by blockage of the elongation of DNA replication by UV-induced lesions in the DNA (a cis effect). However, by introducing an unirradiated E. coli origin (oriC)-dependent replicon into UV-irradiated cells, we have been able to show that the environment of a UV-irradiated cell inhibits initiation of replication from oriC on a dimer-free replicon. We therefore conclude that UV-irradiation of E. coli leads to a trans-acting inhibition of initiation of replication. The inhibition is transient and does not appear to be an SOS function.
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