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  • Title: Analysis of mouse liver metabolites by GC × GC-TOF MS.
    Author: Shi X, Yin X, Zhang X.
    Journal: Methods Mol Biol; 2014; 1198():99-105. PubMed ID: 25270925.
    Abstract:
    Comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry (GC × GC-TOF MS) is a powerful analytical platform for analysis of metabolites in mouse liver. Metabolites are extracted using a solvent mixture of methanol/water (4:1, v/v). The metabolite extracts are analyzed on GC × GC-TOF MS after derivatization. The experimental data are further processed for metabolite identification and quantification. A three-tier method is used for high-accuracy metabolite identification, while metabolite quantification is performed to recognize metabolites with significant abundance differences between sample groups.
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