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  • Title: Effects of short-term oral administration of trimethoprim-sulfamethoxazole on tear production in clinically normal Syrian hamsters.
    Author: Rajaei SM, Ansari Mood M, Selk Ghaffari M, Razaghi Manesh SM.
    Journal: Vet Ophthalmol; 2015 Jan; 18(1):83-5. PubMed ID: 25273510.
    Abstract:
    OBJECTIVE: To determine effects of 14 days of oral administration of trimethoprim-sulfamethoxazole on aqueous tear production in clinically normal Syrian hamsters. ANIMAL STUDIED: Fifteen healthy adult Syrian hamsters. PROCEDURE: Baseline phenol red thread test (PRTT) values were recorded 1 day prior to treatment. Eight hamsters in treated group received 15 mg/kg trimethoprim-sulfamethoxazole orally twice a day for 14 days. The remaining seven hamsters were used as untreated controls and received a placebo. All ophthalmic tests were performed without chemical restraint. PRTT values were evaluated in both eyes of all Syrian hamsters using a commercial PRTT strip of a single lot number. RESULTS: The mean ± SD baseline PRTT values for treatment group and control group were 7.25 ± 1.3 mm/15 s and 5.42 ± 1.13 mm/15 s, respectively. After 14 days of drug administration, the mean ± SD PRTT values for treatment group and control group were 5.62 ± 1.5 and 5.64 ± 0.74, respectively. Significant decreases in the PRTT values, compared with baseline values, were observed in the treatment group on day 15 (P = 0.042). CONCLUSIONS: Trimethoprim-sulfamethoxazole decreased tear production in the hamster in this study.
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