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  • Title: The activity of the red blood cell Ca pump is decreased in hemolytic anemia of the beagle dog.
    Author: Hinds TR, Hammond WP, Maggio-Price L, Dodson RA, Vincenzi FF.
    Journal: Blood Cells; 1989; 15(2):407-20; discussion 421-6. PubMed ID: 2527573.
    Abstract:
    A mild hereditary nonspherocytic anemia in Beagle dogs was studied. Compared to RBCs from normal dogs, RBCs from hemolytic Beagles were larger on average, contained more potassium, and exhibited an approximately 50% decrease in rate of loss of ATP induced by Ca and the ionophore, A23187. Under certain conditions, this rate of ATP loss can be taken as a measure of the Ca pump ATPase activity of intact RBCs. From RBC fractionation studies it appeared that the defective Ca pump ATPase was acquired during the relatively short life-span of the hemolytic RBC. Significant loss of Ca pump ATPase may be causally related to the hemolytic anemia. The mechanism(s) by which Ca pump ATPase activity is lost in this hemolytic anemia remain(s) to be determined.
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