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  • Title: Synthesis and biological evaluation of 4,6-diethyl-1,3,4,5-tetrahydropyrano[4,3-b]indole-4-acetic acid, an isomer of etodolac.
    Author: Hughes P, DeVirgilio J, Humber LG, Chau T, Weichman B, Neuman G.
    Journal: J Med Chem; 1989 Sep; 32(9):2134-7. PubMed ID: 2527995.
    Abstract:
    The synthesis of 4,6-diethyl-1,3,4,5-tetrahydropyrano[4,3-b]indole-4-acetic acid, an isomer of the antiinflammatory agent etodolac, is described. The compound was found to have an ED50 of 3 mg/kg po in the rat curative adjuvant arthritis assay, and an IC50 of 50 nM for inhibiting prostaglandin production in cultured chondrocytes.
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