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  • Title: Dural-based Rosai-Dorfman disease: differential diagnostic considerations.
    Author: Prayson RA, Rowe JJ.
    Journal: J Clin Neurosci; 2014 Nov; 21(11):1872-3. PubMed ID: 25281034.
    Abstract:
    Extranodal sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) is a non-neoplastic condition that has rarely been reported to involve the central nervous system. This report documents a 28-year-old man with Rosai-Dorfman disease who presented with a seizure and a dural-based mass that was thought to represent a meningioma. Resection showed a lesion marked by large, S-100 protein immunoreactive histiocytic cells with intermixed benign lymphocytes and plasma cells. Emperipolesis with intracytoplasmic lymphocytes and plasma cells was present. Differential diagnostic considerations will be discussed.
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