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  • Title: [Pharmacological tolerance to medical therapy of organophosphate poisoning and ways of tolerance management].
    Author: Iudin MA, Bykov VN, Chepur SV, Sarana AM, Tsygan VN, Anokhin AG.
    Journal: Voen Med Zh; 2014 May; 335(5):26-31. PubMed ID: 25286560.
    Abstract:
    Authors consider causes of low efficiency of antidote therapy and ways of pharmacological tolerance management during medical treatment of organophosphate poisoning. One of the promising ways is a preventive antidote on the base of enzyme agents and allosteric modulators of a cholinesterase activity. Authors showed a expediency of a study of new acetylcholinesterase reactivators, its compositions and ways of drug delivery. Authors specified ways of searching for anticonvulsants from classes of quick-closing benzodiatines and NMDA-antagonists. Authors defined ways of improvement of methods of special antidotes delivery with targeted transport system. Authors made an assumption about the necessity of symptomatic treatment.
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