These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Mapping the accumulation of co-infiltrating CNS dendritic cells and encephalitogenic T cells during EAE.
    Author: Clarkson BD, Walker A, Harris M, Rayasam A, Sandor M, Fabry Z.
    Journal: J Neuroimmunol; 2014 Dec 15; 277(1-2):39-49. PubMed ID: 25288303.
    Abstract:
    Evidence from experimental autoimmune encephalomyelitis (EAE) suggests that CNS-infiltrating dendritic cells (DCs) are crucial for restimulation of coinfiltrating T cells. Here we systematically quantified and visualized the distribution and interaction of CNS DCs and T cells during EAE. We report marked periventricular accumulation of DCs and myelin-specific T cells during EAE disease onset prior to accumulation in the spinal cord, indicating that the choroid plexus-CSF axis is a CNS entry portal. Moreover, despite emphasis on spinal cord inflammation in EAE and in correspondence with MS pathology, inflammatory lesions containing interacting DCs and T cells are present in specific brain regions.
    [Abstract] [Full Text] [Related] [New Search]