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Title: Ipilimumab-induced hepatitis on 18F-FDG PET/CT in a patient with malignant melanoma. Author: Raad RA, Pavlick A, Kannan R, Friedman KP. Journal: Clin Nucl Med; 2015 Mar; 40(3):258-9. PubMed ID: 25290291. Abstract: A 78-year-old man with metastatic malignant melanoma underwent a restaging 18F-FDG PET/CT after initiation of ipilimumab therapy, a Food and Drug Administration-approved human monoclonal antibody targeting CTLA-4. PET/CT demonstrated intense FDG uptake fusing to poorly circumscribed hypodensities throughout the liver. Patient was experiencing high-grade fever, chills, and generalized fatigue at the time of imaging, as well as mildly elevated liver function tests. Patient was subsequently treated with corticosteroids for suspected ipilimumab-induced hepatitis, and the patient rapidly improved clinically. Follow-up PET/CT 2 months later revealed complete resolution of abnormal FDG uptake in the liver, confirming the diagnosis of ipilimumab-induced hepatitis.[Abstract] [Full Text] [Related] [New Search]