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  • Title: [Sumatriptan plus naproxen for acute migraine attacks in adults].
    Author: Schytz HW, Bendtsen L.
    Journal: Ugeskr Laeger; 2014 Aug 04; 176(32):. PubMed ID: 25292477.
    Abstract:
    It is of great importance to improve acute treatment of migraine attacks. Non-steroidal anti-inflammatory drugs (NSAID) and triptans have different anti-nociceptive effects, so a combination of these could theoretically lead to more effective acute migraine treatment. A recent meta-analysis investigated the combined effect of sumatriptan and naproxen and found it to be more effective than sumatriptan alone. However, the number needed to treat was high. Combined sumatriptan/naproxen should be reserved to those without efficient response to triptans.
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