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  • Title: [Effect of hepatic failure upon the pharmacokinetics of cefixime].
    Author: Singlas E, Lebrec D, Gaudin C, Montay G, Roche G, Taburet AM.
    Journal: Presse Med; 1989 Oct 11; 18(32):1587-8. PubMed ID: 2530538.
    Abstract:
    Modifications of cefixime kinetics due to severe impairment of liver function were determined in 9 cirrhotic patients. Cefixime was administered as a single dose of 200 mg and levels were measured by HPLC. Maximum serum concentrations and area-under-the-curves of serum concentrations were not modified. The time for maximum serum concentration was delayed and the cefixime half-life in serum was prolonged, as a reflect of increased volume of distribution resulting from ascites and hypoalbuminemia. Renal clearance increased in these patients, possibly because of reduced extra-renal clearance. No metabolite was detected in serum or urine. Modifications of cefixime kinetics resulting from impaired hepatic function were modest and did not require specific dosage adjustment.
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