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  • Title: [Pharmacokinetic interaction of cefixime and 2 antacids. Preliminary results].
    Author: Petitjean O, Brion N, Tod M, Montagne A, Nicolas P.
    Journal: Presse Med; 1989 Oct 11; 18(32):1596-8. PubMed ID: 2530541.
    Abstract:
    A crossover study was undertaken in 8 healthy volunteers to evaluate the pharmacokinetics of cefixime administered orally alone or combined with an antacid. Each subject received successively: cefixime alone, Maalox followed 30 min later by cefixime, then Maalox followed 4 hours later by cefixime and finally Alka-Seltzer followed 30 min later by cefixime. Sixteen blood samples were drawn from 0 to 24 hours after oral administration, and plasma cefixime parameters were determined, using a HPLC assay. Four parameters were used to detect a possible interaction: Cmax, Tmax, AUCO-N and AUCO-alpha. No significant difference was observed between the four parameters. Thus, poor absorption of cefixime when combined with an antacid can be ruled out.
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