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  • Title: [Age-related changes of the hypothalamic-pituitary-adrenal axis: experimental studies in primates].
    Author: Goncharova ND.
    Journal: Adv Gerontol; 2014; 27(2):269-74. PubMed ID: 25306658.
    Abstract:
    The article presents a review of the results of the author's works that examine the character of age-related changes of the hypothalamic-pituitary-adrenal (HPA) axis in primates during aging in basal conditions, including disturbances of its circadian rhythms and in conditions of its inhibition and activation by specific stimuli. In addition, the original data are presented on the peculiarities of the HPA axis functioning under acute psycho-emotional stress taking into account the time of day and individual features of the adaptive behavior of animals, severe chronic stress caused by hemoblastosis process and repeated mild psycho-emotional stress impact. Age disturbances in the HPA axis functioning are of pathophysiological significance for the development of stress- and age-related pathologies and progression of the aging process. Individuals with depression adaptive behavior are most vulnerable to stress and pathological aging.
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