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  • Title: [The anomalies of choroidal and retinal blood flow in retinitis pigmentosa patients].
    Author: He T, Li M, Yin X, Sun X, Wang L, Yang W, Li G.
    Journal: Zhonghua Yan Ke Za Zhi; 2014 Jul; 50(7):518-22. PubMed ID: 25312461.
    Abstract:
    OBJECTIVE: To study changes of blood flow of ophthalmic artery (OA), central retinal artery (CRA) and posterior ciliary artery (PCA) in patients with primary retinitis pigmentosa. METHODS: Color Doppler flow imaging (CDIF) was used in 184 cases (184 eyes) of RP patient. The peak systolic velocity (PSV), end diastolic velocity (EDV), time-averaged maximum velocity (TAMV), pulsatility index (PI) and resistance index (RI) were measured in OA, CRA and PCA separately. Data was analyzed statistically by One-Sample T Test to compare changes of these parameters between RP and normal group. RESULTS: Concerning RP group, in OA, the PSV,EDV, TAMV[ (33.05 ± 8.62) , (7.74 ± 3.04) , (14.16 ± 4.43) cm/s] vs normal group[ (31.47 ± 9.63) , (7.11 ± 2.34) , (12.44 ± 3.64) cm/s] were increased, the differences were statistically significant (t = -2.481, 2.820, 5.253, P < 0.05). But the PI in OA of RP(1.87 ± 0.73) vs normal group (2.02 ± 0.71) was deceased, the difference was statistically significant (t = -2.794;P < 0.05). Concerning RP group, in CRA, the PSV, EDV, TAMV, PI and RI [(5.30 ± 1.36), (2.11 ± 0.49), (3.01 ± 0.680) cm/s], [ (1.05 ± 0.28) , (0.60 ± 0.18) ] vs normal group [(10.82 ± 2.97) , (3.28 ± 1.11), (5.50 ± 2.06) cm/s], [ (1.48 ± 0.49), (0.71 ± 0.08) ] were decreased, the differences were statistically significant (t = -55.186, -32.015, -49.634, -20.430, -8.704, P < 0.05). Concerning RP group, in PCA, the PSV, EDV, TAMV, PI and RI [(7.60 ± 1.95), (2.59 ± 0.58), (4.07 ± 1.00) cm/s], [ (1.23 ± 0.28), (0.65 ± 0.80) ] vs normal group [(11.61 ± 3.41), (3.34 ± 1.25), (5.83 ± 1.91) cm/s], [ (1.49 ± 0.43), (0.70 ± 0.09)] were decreased, the differences were statistically significant (t = -28.097, -17.541, -23.842, 12.445, -8.720, P < 0.05). CONCLUSIONS: Hemodynamic abnormal changes of OA, RCA and PCA in RP patients possibly suggest the role of blood supply in occurrence or development of RP. Maintaining normal ocular blood flow may be able to offer a new way for prevention and treatment for RP.
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