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  • Title: Clinical features of 10 fetuses with prenatally diagnosed parvovirus b19 infection and fetal hydrops.
    Author: Kyeong KS, Won HS, Lee MY, Shim JY, Lee PR, Kim A.
    Journal: Fetal Pediatr Pathol; 2015 Feb; 34(1):49-56. PubMed ID: 25313841.
    Abstract:
    OBJECTIVES: To evaluate the clinical features of fetuses with prenatally diagnosed parvovirus B19 infection and fetal hydrops. METHODS: Parvovirus infection was diagnosed by PCR analysis of amniotic fluid or fetal blood. Fetal anemia was assessed by Doppler measurements of the middle cerebral artery peak systolic velocity (MCA-PSV) and confirmed by fetal blood. Intrauterine transfusions (IUT) were performed only if the MCA-PSV was > 1.5°MoM. RESULTS: In our study population 10 cases of parvovirus infection which were associated with fetal hydrops were reviewed. The median gestational age at diagnosis was 21 (16.3-24.2) weeks. Five of our cases received IUT and four fetuses survived. The remaining five cases were managed conservatively and two fetuses survived. CONCLUSIONS: The survival rate for parvovirus infection associated with fetal hydrops was 60%. MCA-PSV and IUT are useful for the management and treatment of fetal anemia due to parvovirus infection.
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