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  • Title: miR-545 inhibited pancreatic ductal adenocarcinoma growth by targeting RIG-I.
    Author: Song B, Ji W, Guo S, Liu A, Jing W, Shao C, Li G, Jin G.
    Journal: FEBS Lett; 2014 Nov 28; 588(23):4375-81. PubMed ID: 25315416.
    Abstract:
    Pancreatic ductal adenocarcinoma (PDAC) ranks fourth on the list of cancer-related causes of death. Deregulation or dysfunction of miRNAs contribute to cancer development. In this study, we found that low miR-545 level and high RIG-I protein in PDAC tissues were both correlated with low survival rate. MiR-545 up-regulation inhibited PDAC cell lines growth and vice versa. 3'UTR of RIG-I was targeted by miR-545. Thus we concluded that low miR-545 levels in PDAC promote tumor cells growth, and this is associated with reduced survival in PDAC patients. MiR-545 exerts its effects by directly targeting RIG-1.
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