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  • Title: A novel Pd-catalyzed N-dealkylative carbonylation of tertiary amines for the preparation of amides.
    Author: Fang T, Gao XH, Tang RY, Zhang XG, Deng CL.
    Journal: Chem Commun (Camb); 2014 Dec 07; 50(94):14775-7. PubMed ID: 25317723.
    Abstract:
    A novel and convenient protocol for the formation of amides via palladium-catalyzed N-dealkylative carbonylation of alkyl tertiary amines has been developed. In the presence of PdCl2(PhCN)2, CuO, PhCN and CO, a range of substituents on both aryl iodides and alkyl tertiary amines were compatible with the reaction to afford a series of N,N-disubstituted amides in moderate to excellent yields.
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