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  • Title: Ascorbic acid inhibits [3H]SCH-23390 binding to striatal dopamine D1 receptors.
    Author: Wiener HL, Lajtha A, Sershen H.
    Journal: J Recept Res; 1989; 9(4-5):331-9. PubMed ID: 2531799.
    Abstract:
    The present study describes the inhibition of [3H]SCH-23390 binding to striatal dopamine D1 receptors in the presence of ascorbic acid. Specific [3H]SCH-23390 binding was maximally inhibited by 0.1 mM ascorbic acid. As determined by Scatchard analysis the binding in the presence of 0.01, 0.1, or 10 mM ascorbic acid was consonant with non-competitive inhibition with a 26%, 38%, or 19% decrease, respectively, in the maximal number of binding sites; the affinity of these binding sites was not affected. Inhibition of [3H]SCH-23390 binding by ascorbic acid was reversible; striatal homogenates incubated with 0.1 mM ascorbic acid and subsequently washed free of ascorbic acid had the same Scatchard parameters as untreated preparations.
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