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  • Title: Blockade of 8-OH-DPAT-induced feeding by dopamine antagonists.
    Author: Muscat R, Montgomery AM, Willner P.
    Journal: Psychopharmacology (Berl); 1989; 99(3):402-8. PubMed ID: 2531902.
    Abstract:
    Feeding elicited by the 5HT1A agonist 8-OH-DPAT was blocked by pretreatment with the DA antagonists SCH-23390 and sulpiride, in two experiments conducted in non-deprived rats and in three experiments conducted after 4 h food deprivation. In deprived animals, 8-OH-DPAT prolonged the initial period of feeding. However, in non-deprived animals, 8-OH-DPAT delayed the onset of eating, and suppressed post-prandial resting; both SCH-23390 and sulpiride restored the normal pattern of behaviour. All three drugs suppressed grooming. The results suggest that 8-OH-DPAT elicits feeding by a secondary disinhibition of activity postsynaptic to DA neurons. The consequences of this mechanism for the interpretation of 8-OH-DPAT-induced feeding are discussed.
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