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  • Title: [Photogeneration of singlet molecular oxygen by the components of hematoporphyrin IX derivative].
    Author: Egorov SIu, Tauber AIu, Krasnovskiĭ AA, Nizhnik AN, Nokel' AIu, Mironov AF.
    Journal: Biull Eksp Biol Med; 1989 Oct; 108(10):440-2. PubMed ID: 2532043.
    Abstract:
    The photosensitized luminescence of singlet molecular oxygen has been studied in aqueous and alcoholic solutions of hematoporphyrin IX (HP) and di- and oligomeric components of "hematoporphyrin derivative" (photofrin II) which is known to be used as a drug in photodynamic tumor therapy. The quantum yields of 1O2 generation (gamma delta) by these compounds have been determined. It was found that the highest gamma delta values are characteristic of alcoholic and micellar detergent aqueous solutions. In detergent-free aqueous solutions containing mainly associated porphyrin molecules, gamma delta is much lower (5-30%), polymeric photofrin components being considerably less active than HP. Both localization of porphyrins in hydrophobic loci and high photosensitizing activity in lipid phase are supposed to play the key role in tumor photodestruction.
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