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  • Title: [Clinico-laboratory evaluation a new sustained-release preparation of anhydrous theophylline].
    Author: Gandola L, Aiolfi S, Soccini F, Patrini G, Capellini G, Scartabellati A, Ghio L, Mauri F.
    Journal: Clin Ter; 1989 Dec 15; 131(5):293-7. PubMed ID: 2532583.
    Abstract:
    The clinical effectiveness and the pharmacokinetic parameters of a once-a-day sustained release preparation of anhydrous theophylline were studied in a trial carried out on 10 adult patients affected by bronchial asthma or chronic obstructive lung disease. Treatment with this new theophylline preparation allowed us to obtain mean serum concentrations within the therapeutic range (5-20 mcg/ml) which remained quite constant during 24 hours. All patients evidenced improvement of dyspnea and of the signs of bronchospasm. Tolerability was very good.
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