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  • Title: Dramatic osteonecrosis of the jaw associated with oral bisphosphonates, periodontitis, and dental implant removal.
    Author: Fernández Ayora A, Herion F, Rompen E, Reginster JY, Magremanne M, Lambert F.
    Journal: J Clin Periodontol; 2015 Feb; 42(2):190-5. PubMed ID: 25327450.
    Abstract:
    INTRODUCTION: Osteoporosis affects millions of elderly patients, and anti-resorptive drugs (ARD) such as bisphosphonates (BP) represent the first-line therapy. Despite the benefits related to the use of these medications, osteonecrosis of the jaw is a significant complication in a subset of patients receiving these drugs. CASE PRESENTATION: This report documents a case of dramatic bisphosphonate-related osteonecrosis associated with periodontitis and dental implant removal in an osteoporotic patient treated with per os bisphosphonates for an uninterrupted period of 15 years. CONCLUSION: The aim of this report was to discuss the administration period of BP in the treatment of osteoporosis, the decision-making and clinical management of severe MRONJ and the indications for dental implant placement in these specific patients.
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