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  • Title: Modification of marine natural product ningalin B and SAR study lead to potent P-glycoprotein inhibitors.
    Author: Yang C, Wong IL, Jin WB, Jiang T, Chow LM, Wan SB.
    Journal: Mar Drugs; 2014 Oct 17; 12(10):5209-21. PubMed ID: 25329704.
    Abstract:
    In this study, new marine ningalin B analogues containing a piperazine or a benzoloxy group at ring C have been synthesized and evaluated on their P-gp modulating activity in human breast cancer and leukemia cell lines. Their structure-activity relationship was preliminarily studied. Compounds 19 and 20 are potent P-gp inhibitors. These two synthetic analogues of permethyl ningalin B may be potentially used as effective modulators of P-gp-mediated drug resistance in cancer cells.
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