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  • Title: Central nicotinic acetylcholine receptors in the chicken and Drosophila CNS: biochemical and molecular biology approaches.
    Author: Betz H, Gundelfinger ED, Hermans-Borgmeyer I, Sawruk E, Schloss P, Schmitt B.
    Journal: EXS; 1989; 57():183-9. PubMed ID: 2533091.
    Abstract:
    Putative neuronal nicotinic acetylcholine receptors (nAChRs) were investigated using biochemical and molecular biology approaches. In the chick visual system, a nicotinic cholinergic binding site was localized on a polypeptide of Mr 57,000 using the potent antagonist, alpha-bungarotoxin (alpha-Btx). Ion flux experiments indicate that this membrane protein is different from the toxin-insensitive nAChR present in vertebrate neurons. Crosshybridization with a Torpedo nAChR cDNA probe allowed isolation of a cholinergic receptor cDNA (ARD) from the Drosophila CNS. Analysis of the corresponding gene, its transcripts and the ARD protein are presented here.
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