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  • Title: Antimicrobial γ-AApeptides (WO2013112548): a patent evaluation.
    Author: Teng P, Wu H, Lin L, Cai J.
    Journal: Expert Opin Ther Pat; 2015 Jan; 25(1):111-8. PubMed ID: 25331592.
    Abstract:
    The patent application WO2013112548 claims a new class of peptidomimetics - γ-AApeptides with potent and broad-spectrum antimicrobial activity. These γ-AApeptides are active against both Gram-positive and Gram-negative bacteria, including medicinally relevant drug-resistant pathogens. They are believed to exert bactericidal function by mimicking the membrane disruption mechanism of host-defense peptides. As such, they may provide an alternative approach for antimicrobial development combating antibiotic resistance.
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