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  • Title: IgE and inflammatory cells: the cellular networks in allergy.
    Author: Dessaint JP, Capron A.
    Journal: Int Arch Allergy Appl Immunol; 1989; 90 Suppl 1():28-31. PubMed ID: 2533177.
    Abstract:
    The expression by macrophages, eosinophils, and platelets of IgE receptors (Fc epsilon RII) confers on these cells, present or recruited at the site of allergen challenge, a direct role in the development of adverse allergic reactions. The IgE-dependent activation of macrophages, eosinophils, and platelets is moreover inhibited by antiallergic drugs such as disodium cromoglycate or nedocromil. This network of IgE-dependent effector cells is controlled by immunoregulatory pathways which can be target of desensitization therapy. Contrary to their deleterious role in allergic disorders, IgE- and Fc epsilon RII-bearing cells play a decisive role in the immune defense against helminth parasites, therefore pointing to a dualistic function of IgE.
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