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  • Title: Systemic and regional haemodynamic responses to microinjection of 5-HT agonists in the rostral ventrolateral medulla in the rat.
    Author: Lovick TA.
    Journal: Neurosci Lett; 1989 Dec 15; 107(1-3):157-61. PubMed ID: 2533333.
    Abstract:
    In anaesthetised rats bilateral microinjection of 2 nmol 5-HT or the agonists 5-carboxyamidotryptamine (5-CT), 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) into nucleus paragigantocellularis lateralis produced a fall in blood pressure and heart rate, an increase in hindlimb vascular conductance but no significant change in renal conductance. In contrast, alpha-methyl-5-HT injected into the same region had no such effects. It is suggested that these cardiovascular effects are mediated by activation of 5-HT1A receptors. The possibility that there may be differences between species with respect to central 5-HT receptor-mediated cardiovascular effects is also discussed.
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