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  • Title: Diastereoselective synthesis of functionalized spirocyclopropyl oxindoles via P(NMe2)3-mediated reductive cyclopropanation.
    Author: Zhou R, Yang C, Liu Y, Li R, He Z.
    Journal: J Org Chem; 2014 Nov 07; 79(21):10709-15. PubMed ID: 25333339.
    Abstract:
    A P(NMe2)3-mediated reductive cyclopropanation reaction of α-keto esters or amides with isatin-derived alkenes has been developed, providing efficient and diastereoselective synthesis of highly functionalized spirocyclopropyl oxindoles bearing two all-carbon quaternary centers. This reaction also represents a complementary and nonmetal-involving protocol for the challenging cyclopropanation of electron-deficient alkenes.
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